"Please follow these instructions:1. Stack the pages of this letter neatly. 2. Roll the pages up into a cylinder. 3. Smack yourself over the head with it. 4. Repeat. You complete ass."

"As computers have become more powerful, computer graphics have advanced to the point where it's possible to create photo-realistic images. The bottleneck wasn't, 'How do we make pixels prettier?' It was, 'How do we engage with them more?'."

"Antibiotics are a very serious public health problem for us, and it's getting worse. Resistant microbes outstrip new antibiotics. It's an ongoing problem. It's not like we can fix it, and it's over. We have to fight continued resistance with a continual pipeline of new antibiotics and continue with the perpetual challenge."

"Music has to be written while people are still excited about a particular melodic or rhythmic sequence. The idea doesn't come out the same if we're not really excited about it."

"As far as Iraq, the important thing is that the Taliban is gone in Afghanistan, three-quarters of the al-Qaida leadership is either dead or in jail, and we now have Saudi Arabia working with us, Pakistan working with us."

"Much as slavery in the United States was part of a larger Atlantic Slave System, so America’s War of Independence was an outgrowth of Europe’s Seven Years’ War — from 1756 to 1763 — and also a precursor or harbinger of the French and Haitian revolutions and of the subsequent Latin American wars for independence from Spain."